Non-invasive markers of coronary reperfusion in acute myocardial infarction.

variance, such as intense physical exercise, advanced heart failure or diabetic neuropathy. Spectral analysis of RR variability does not measure tonic nerve activity of any of the two autonomic outflows, but only provides an estimate of the continuous interaction between sympathetic and vagal modulatory activities with the sino-atrial node function, examined in closed loop conditions. Large scale normative studies are still not available, and it will be important to titrate the results in a clinical setting. In spite of the remaining difficulties and uncertainties, the introduction of portable equipment with more user-friendly standardized procedures, will prove essential to open the door between the computer room and the clinical ward. M. PAGANI University of Milano and CNR Milano, Italy References